| Airway | Large head and tongue · short neck · larynx higher (C2–C3) and anterior · floppy U-shaped epiglottis · narrowest at the cricoid (classically) · obligate nasal breathers to ~6 months | Neutral position, not sniffing. Straight blade in neonates |
| Respiratory | Alveolar ventilation : FRC ≈ 5:1 (adult 1.5:1) · high O₂ consumption 6–8 ml/kg/min · compliant chest wall · horizontal ribs · diaphragm-dependent | Very rapid desaturation; fast inhalational induction |
| Cardiovascular | Rate-dependent cardiac output — fixed stroke volume · high vagal tone | Bradycardia is catastrophic; commonest cause is hypoxia |
| Thermoregulation | High surface-area-to-volume · non-shivering thermogenesis via brown fat · cannot shiver | Rapid heat loss — warm the theatre and the fluids |
| Renal / hepatic | Immature GFR until ~1 year · immature enzymes · low albumin | Prolonged drug effects; higher free fraction |